Mechanism of Action for Promensil in Regard to T47D Cell Proliferation
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open in viewerPromensil is an over-the-counter phytoestrogen supplement marketed to menopausal women as an alternative to hormone replacement therapy. Prior studies looking into the relationship between Promensil and breast cancer have yielded inconsistent results, so the goal of this study was to investigate the relationship between Promensil and cell proliferation in an estrogen receptor-positive breast epithelial cell line. It was found that introducing Promensil to T47D cells correlated to decreased cell counts, and markers for the cell cycle, DNA replication, and apoptosis were followed to investigate the mechanism behind this decrease. Future studies should investigate the receptor status of the triple negative control line used and should explore the protein expression in this line as well.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-050221-182016
- 21201
- Advisor
- Year
- 2021
- Date created
- 2021-05-02
- Resource type
- Major
- Rights statement
- Dernière modification
- 2021-08-28
Relations
- Dans Collection:
Contenu
Articles
La vignette | Titre | Visibilité | Embargo Release Date | actes |
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Huber MQP (final).pdf | Public | Télécharger |
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