Diabetes affects over 500 million people worldwide, with at least 15% of people developing at least one diabetic foot ulcer in their lifetime. Diabetic foot ulcers are slow-healing wounds due to the hyperglycemic environment, which inhibits cell proliferation at the wound site. Therefore, there is a need for a dressing that promotes wound healing and cell proliferation under hyperglycemic conditions. We developed a gelatin-based hydrogel, incorporating decellularized adipose extracellular matrix and microparticles loaded with growth factors, that enhances wound healing processes. Through sustained drug release, the final hydrogel product significantly increased cell proliferation in the hyperglycemic in vitro wound model.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Pace, Zoe
• Enax, Mikaela
• Keang, Tera
• Ferullo, Gabriela
• Smith, Sydney

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042324-121425
• 121377

Mot-clé

• Hydrogel
• Wound Healing
• Diabetic Foot Ulcers
• Extracellular Matrix
• Microparticles
• Growth Factors

Advisor

• Ambady, Sakthikumar

Year

• 2024

Date created

• 2024-04-23

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Source

• E-project-042324-121425

Rights statement

• In Copyright

Dernière modification

• 2024-05-28